There might be a new way to deliver a drug to a target tissue. The Methodist Hospital Research Institute may have found a way to prevent the body from recognizing and destroying them before they deliver their drug payloads.
Nanoparticles are coated with patients own cell membrane, e.g. white blood cell membrane. The ability of the body’s defenses to destroy nanoparticles is a major barrier to the use of nanotechnology in medicine. The researcher group developed a procedure to separate membranes from cell innards. These separated membranes are used to cover the nanoparticles. These first drug-carrying nanoparticles, leukolike vectors, acts and looks like cells.
In future the researcher group is willing to make leukolike vectors totally synthetically because it is hard to get enough patients’ white blood cells. So they want to optimize their harvesting by cell culturing. For now it’s the most effective way to use white blood cells.
Reseachers has generally focused on getting the particles to recognize specific tissue and to release drugs there. Over time the membrane lipids and proteins will break away, leaving the nanoparticles to degrade naturally after releasing their payload.
Susanna and Tero