Coated nanoparticles in drug delivery

There might be a new way to deliver a drug to a target tissue. The Methodist Hospital Research Institute may have found a way to prevent the body from recognizing and destroying them before they deliver their drug payloads.

Nanoparticles are coated with patients own cell membrane, e.g. white blood cell membrane. The ability of the body’s defenses to destroy nanoparticles is a major barrier to the use of nanotechnology in medicine. The researcher group developed a procedure to separate membranes from cell innards. These separated membranes are used to cover the nanoparticles. These first drug-carrying nanoparticles, leukolike vectors, acts and looks like cells.

In future the researcher group is willing to make leukolike vectors totally synthetically because it is hard to get enough patients’ white blood cells.  So they want to optimize their harvesting by cell culturing. For now it’s the most effective way to use white blood cells.

Reseachers has generally focused on getting the particles to recognize specific tissue and to release drugs there. Over time the membrane lipids and proteins will break away, leaving the nanoparticles to degrade naturally after releasing their payload.


Susanna and Tero


2 thoughts on “Coated nanoparticles in drug delivery

  1. I think this post made a good point how nanoparticles still don’t work very effectively in drug delivery.
    In class we have discussed a lot how nanoparticles could be used for drug delivery and how they can enter the body and environment easily. Yet we haven’t really discussed how the body reacts to the particles, and how it can attact the foreign particle.
    Nanotechnology is making progress all the time, but there still are issues to overcome to optimize applications, as this post reminds.

  2. I totally agree with Anna. I think that this post made a good point how the nanoparticles could be a really good solution to many problems. But the post also made it clear that the research must go on and that there is a lot to research.
    How ever – this sounds really promising.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s